Natural Compounds as Inhibitors of Human Neutrophil Elastase
نویسندگان
چکیده
منابع مشابه
Molecular docking analysis of natural compounds as Human neutrophil elastase (HNE) inhibitors
In recent years regulation of the enzymatic activity of human neutrophil elastase (HNE) has been the main focus of investigation, due to its potential therapeutic application in medicinal field. In the present study, the docking behaviour of human neutrophil elastase (HNE) with 14 different ligands namely Chrotacumines-A, B, C, GrandolsB, D, G, Rohitukine, Quercitin, Ellagic acid, Artoindonesia...
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Recent evidence shows that human neutrophil elastase inhibitors can be synthesized locally at mucosal sites. In addition to efficiently targeting bacterial and host enzymes, they can be released in the interstitium and in the lumen of mucosa, where they have been shown to have antimicrobial activities, and to activate innate immune responses. This review will address more particularly the pleio...
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Human neutrophil elastase was inactivated by methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Ala-chloromethane. The modified enzyme was crystallized from 40 mM ammonium phosphate, pH 7.0 in the hexagonal space group P6(3) with unit cell parameters a = 74.53 A, b = 74.53 A, c = 70.88 A, alpha = beta = 90 degrees, gamma = 120 degrees. These crystals were resistant to radiation damage and diffracted beyond 1....
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Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic activity could represent effective therapeutics. We present here the synthesis of new thiazol-2-(3H)-ones as an elaboration of potent HNE inhibitors with an isoxazol-5-(2H)-o...
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An imbalance between neutrophil-derived proteases and extracellular inhibitors is widely regarded as an important pathogenic mechanism for lung injury. Despite intense efforts over the last three decades, attempts to develop small-molecule inhibitors for neutrophil elastase have failed in the clinic. Here we discover an intrinsic self-cleaving property of mouse neutrophil elastase that interfer...
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ژورنال
عنوان ژورنال: Planta Medica
سال: 2007
ISSN: 0032-0943,1439-0221
DOI: 10.1055/s-2007-967183